Dipyanone - An old Controversy Resurfaces

Feb 21, 2021

The next iteration of research analgesics could be just as dangerous as isonitazene.

4,4-diphenyl-6-(pyrrolidin-1-yl)heptan-3-one

DIPYANONE (Metamizole) has begun to resurface in the Research Community - a fairly equipotent Morphine alternative, shown to potentially cause Agranulocytosis (can cause fever, sore throat, fatigue and other symptoms flu-like symptoms, which can cause extreme weakening of the immune system). There have even been reports of Dipyrone-induced allergic cholestatic hepatitis. Dipyrone-induced acute kidney injury have also been reported.


Since the "Fentalogue"  crisis has slowly continued, non-opiate derived pain management has been taken the modern approach, while Dipyrone's mechanism od action is fully understood, it is in fact a non opiate alternative, originally found to be reported as  being equipotent to Morphine.

Even the Ministry of Health of many countries are divided on this issue, and in some countries you will find that the use of this drug is completely banned (e.g. USA and the UK), while in other countries this drug has wide spectrum of applications (e.g. Netherlands, Sweden and Serbia). It is a sulfonic acid normally found as a white/almost crystalline powder that is highly soluble in water and ethanol yet unstable in the presence of light.

Since the "Fentalogue"  crisis has slowly continued, non-opiate derived pain management has been taken the modern approach, while Dipyrone's mechanism od action is fully understood, it is in fact a non opiate alternative, originally found to be reported as  being equipotent to Morphine.

In this proposal, not yet verified by other researchers, the metamizole itself breaks down into other chemicals that are the actual active agents. The result is a pair of cannabinoid and NSAID arachidonic acid conjugates. Despite this, studies in animals have found that the CB1 cannabinoid receptor is not involved in the analgesia induced by metamizole.

-Sellkies

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